A new study indicates that the Pfizer vaccine, and thus likely Moderna as they work the same way, induces germinal creation of B cells. This means that immunity with the mRNA vaccines (J&J may be a different matter) is likely to last for years, with boosters needed only if we have a vaccine-evading variant.

I also have not seen a study that indicates undetectable antibodies after 6 to 8 months, quite the opposite in fact. Vaccine fading is not likely to be a short term concern.

Vaccine evading variants IS a potential concern, and if we need early boosters it will be because of that not vaccine fade.

And pursuing an elimination strategy would only work if we could get every human being on the planet (with the exception of a few very isolated communities) vaccinated at once and get every human being on the planet to agree to those mitigation measure AND pay every business to ensure they stay afloat.

Otherwise it will just come back in from countries which can't afford to do all of that.

Two other things:

1. Despite the variants, coronaviruses are actually pretty slow mutating viruses. Their large genomes are protected by a proofreading mechanism. We're only seeing these variants because a. There are so many cases and b. The virus is still adapting to its new host.

2. There has yet to be a significant concern with vaccine resistance except in fast evolving viruses such as influenza and HIV (which is a different strain in every single patient). SARS-CoV-2 does not fall into these categories. If we get a vaccine-resistant strain it is far more likely to evolve as a result of typical immune evasion in *unvaccinated* populations. To the virus, vaccine-induced immunity and natural immunity aren't distinguishable.